Injectable Peptide Ipamorelin to Increase Muscle Mass CAS
Alias : 696: PN:WO2004005342 PAGE: 46 claimed protein, Ipamorelin,
Appearance: White powder
Grade : Pharmaceutical Grade
Usage :Growth hormone secretagogue receptor is a G protein-coupled
receptorthat binds ghrelin and plays a role in energy homeostasis
and regulation of bodyweight.
|Molecular Formula||C38H49N9O5||Molecular Weight||711.86|
|Appearance of solution||Transparent|
|Colour of solution||Colorless|
|Specific Optical Rotation (c=0.5,95%HAc)||offer|
|Total Impurities(by HPLC)||≤2.00%~0.05%|
|Single Impurity(by HPLC)||≤0.50%~0.08%|
|Water Content(Karl Fischer)||≤4.80%|
|Acetate Content(by HPLC)||≤6.80%|
|Peptide Content(by %N )||≥88.00%|
|Amino Acaid Composition||±10% of theoretical|
|Assay(By anhydrous, acetic acid-free)||95.0%~105.0%|
Ipamorelin (or NNC 26-0161) belongs to regulatory peptides because
it is GH releasing protein; Its chain is quite short and only
consists of five amino acids. Its molecular mass/weight is 711.86
and its molecular formula is C38H49N9O5. Ipamorelin was synthesized
as innovative and novelty mimetic of ghrelin therefore it possesses
ability to enhance gastric motility. There are few ongoing clinical
trials with ipamorelin at the current moment. The first studies on
HGr-peptides including NNC 26-0161 started in early 1990s. Also
this research compound is a selective secretagogue of G-hormone and
ghrelin receptor's agonist. As other proteins ipamorelin reacts
with GHRP-like receptors to release growth hormone from pituitary
gland. But unlike few other peptides of hormones nature this
pentapeptide doesn't release same volume of such compounds as
cortisol and acetylcholine, and that makes it a very good candidate
for future researches. Furthermore, NNC 26-0161 is more stable form
of ghrelin and has longer half-life period, and it causes secondary
effect by making neurons to become excited.
Ipamorelin is a fascinating new muscle building discovery that is
getting a lot of attention in the bodybuilding world.It is a
synthetic peptide that has powerful Growth Hormon releasing
properties.And these GH releasing properties are what is of
interest to athletes and bodybuilders since they can make a
tremendous difference in the amount of muscle you can grow and how
quickly you burn fat.
Ipamorelin is a penta-peptide.(Aib-His-D-2-Nal-D- Phe-Lys-NH2) And,
the strength it displays may very well make regular old Growth
Hormon (GH) obsolete.But what athletes and bodybuilders really want
to know is what is this wonder peptide capable of doing, how is it
used, and how does it compare to the other GHRP peptides?
Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or
three times daily, using a tiny insulin needle to inject.They
usually start with the lower dose since side effects can include
headaches or what feels like a head-rush.Ipamorelin can be taken at
anytime but taking it about 30-45 minutes before a workout would
seem ideal because of the pulse in Growth Hormon (GH) it creates
allowing for maximum growth.
Studies on the effects of Ipamorelin on bone growth, body weight,
and GH release showed some interesting conclusions.In one
experiment, various doses were administered over the course of 15
days to test the group's reactions.
There was a distinct and dose-dependent effect on body weight gain
however, the treatment group did not show a change in total IGF-I
levels.Nor did the treatment group produce serum markers of bone
development.For example, the number of cells in the wide portion of
the tibia (the shinbone) did not change significantly.This is a
good thing because it suggests muscle growth with less potential
for deformity of bone or cartilage.
The reaction of the pituitary to an aggressive i.V.Dose of
Ipamorelin showed that plasma GH levels were notably reduced
whereas they were unchanged after a comparable dose of GHRH.This is
actually a good thing as it suggests that Ipamorelin may not
decrease your body's natural GH production - further demonstrating
that Ipamorelin is a selective GH releaser.
Ipamorelin does not induce hunger making it advantageous to those
on a restricted calorie diet.And obviously, Ipamorelin's
side-effects are enhanced when combined with anabolic steroids
since they too influence Growth Hormon/Insulin Growth Factor
release and production.
Another document states that in healthy swine, Ipamorelin released
GH with a consistency that is very comparable to GHRP-6.Also
noteworthy was that none of the GH releasers tested affected FSH,
LH, PRL or TSH blood serum plasma levels.
Ipamorelin in theory may increase Acetylchloine or Cortisol when
used in higher dosages.However, and increase in Acetylchloine or
Cortisol is even more likely with GHRP-2 and GHRP-6.In fact, in the
case of Ipamorelin, there was little to no rise in Acetylcholine
and Cortisol blood plasma levels even at injections more than 200
times higher than the effective dosage for comparable GH release.
This clearly proves that Ipamorelin is the first successful GHRP
receptor agonist or chemical that binds to a receptor of a cell and
triggers a response by that cell with a specific selectivity for
the promotion of GH release by itself.
Another advantage to Ipamorelin is that it doesn't cause sudden
spikes in prolactin or cortisol as does GHRP-2 and
GHRP-6.Ipamorelin is slower in its delivery unlike GHRP's which
spike GH levels at a more rapid rate.The slower release is more
natural and has a more sustained effect.
All in all it looks as if Ipamorelin is the new wave in GH
releasing peptides.It appear to be more potent, longer lasting and
potentially safer to use in the long run.More studies are being
conducted all the time but as it stands, Ipamorelin looks like a
serious contender in the arsenal of anabolic advancement.
Ipamorelin is an interesting peptide taken 300mcg twice daily or
you could lower the dose for 3 times daily, side effects are head
rushs, I would recommend taking this 30 minutes before workout
,with gear, Ipamorelin is a new and potent synthetic pentapeptide
which has distinct and specific growth hormone (GH)-releasing
properties. With the objective of investigating the effects on
longitudinal bone growth rate , body weight , and GH release,
Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was
injected three times daily for 15 days to test subjects, After
intravital Tetracycline labelling on days 0, 6, and 13, LGR was
determined by measuring the distance between the respective
fluorescent bands in the proximal tibia metaphysis. Ipamorelin
dose-dependently increased LGR from 42 μm/day in the vehicle group
to 44, 50, and 52 μm/day in the treatment groups . There was also a
pronounced and dose-dependent effect on body weight gain. The
treatment did not affect total IGF-I levels, or serum markers of
bone formation and resorption. The number of tartrate-resistant
acid phosphatase-positive multinuclear cells in the metaphysis of
the tibia did not change significantly with treatment. The
responsiveness of the pituitary to a provocative i.v. dose of
Ipamorelin or GHRH showed that the plasma GH response was
marginally reduced , after Ipamorelin, but unchanged after GHRH.
The pituitary GH content was unchanged by Ipamorelin treatment.
Whether Ipamorelin or other GH secretagogues may have a place in
the treatment of children with growth retardation requires
demonstration in future clinical studies. Before closing Ipamorelin
is the most selective GH releaser you can get.
Ipamorelin doesn't create bumps in either prolactin or cortisol
like GHRP-2 and -6. Ipa is a rifle bullet, not a shotgun blast like
other GHRP's. Also it's great for those on relatively calorie
restricted diets because it doesn't stimulate appetite
Ipamorelin and Peptides are the way of the future ,expect in the
next 5 years or less a dramatic change in the way we train and take
the bodybuilding world by storm.
Build tight lean muscle, reduce body fat and decrease water
retention with Ipamorelin from Forever Young Medical Institute.
Useful for: Bodybuilders looking to tighten up; Ordinary people for
fat loss and quality shredded muscle gain; Older persons looking
for anti-aging benefits; Rapid injury rehabilitation;
GH Peptides series
|T-A003||CJC-1295 with DAC||2mg|
|T-A004||CJC-1295 without DAC||2mg|
|T-A0015||pentadecapeptide BPC 157||2mg|
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